For example, consider:
BAM!
In your face, RMSD! Big yellow arrow pwns you! The RMSDs are falling! Time to SELL SELL SELL!
Reference: C.-K. Siu et al., Optimization of Parameters Used in Algorithms of Ion-Mobility Calculation for Conformational Analyses, J. Phys. Chem. B doi:10.1021/jp910858z